Laser Microdissection

Laser Microdissection (LMD) has recently gained a lot of interest as the existing procedure was developed into a cell culture compatible technique. In principal LMD works by placing and cultivating a sample on an extremely thin film of around 2µm thickness. With a laser beam, the sample of interest is then cut out by slicing the foil around the sample as indicated in the picture below. In a third step, the loose foil is lifted and transported to a place of further sample processing like a cap, vial, or tube.

Originally, LMD was developed to achieve small biopsies from tissue samples. However, recently the method was developed into a tool that allows the cultivation, selection, and further processing of a set of cells. The existing carriers reflect mainly research on tissue. Therefore, our two LMD Slides close a gap and allow cultivation and future LMD work on the same slide. That solution is achieved by offering the µ-Slide 18 well and the µ-Slide Angiogenesis as an LMD version with a foil of 2µm thickness. The Slides allow the cultivation of up to 18 different samples of different cells and their future processing. So for instance transfected cells can be separated from non transfected ones. In the future, more carriers will be offered with the LMD film.